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Benzhexol Tablets Bp 5mg


  • Benzhexol Tablets BP 2mg: White, circular, flat bevelled-edge tablet plain on both sides. Each tablet contains: Benzhexol Hydrochloride BP 2mg.
  • Benzhexol Tablets BP 5mg: White, circular, biconvex  tablet embossed 'COSMOS' on one side and a breakline on the other side. Each tablet contains: Benzhexol Hydrochloride BP 5mg.


Benzhexol Hydrochloride is a tertiary amine antimuscarinic with actions similar to those of atropine. It also has a direct antispasmodic action on smooth muscle. The exact mechanism of action of Benzhexol in parkinsonian syndrome may result from blockade of efferent impulses and from central inhibition of cerebral motor centers.


Benzhexol Hydrochloride is well absorbed from the gastro-intestinal tract and has been stated to exert an effect within 1 hour of a dose by mouth. Following oral administration of Benzhexol there was an initial elimination phase with an estimated half-life of 5.33 hours followed by a terminal elimination phase with an estimated half-life of 32.7 hours.


Benzhexol is employed in the symptomatic treatment of parkinsonism including the alleviation of the extrapyramidal syndrome induced by drugs such as phenothiazines.


Idiopathic parkinsonism: Initial dose of 1mg daily gradually increased over a period of several days by increments of 2mg to 6 to 10mg daily according to the response of the patient.
Drug-induced extrapyramidal symptoms: 5 to 15mg daily.


Benzhexol needs to be used with caution in children and the elderly, in patients with or at risk of urinary retention and in those with paralytic ileus or pyloric stenosis. Caution is generally advisable in any patient with diarrhoea. It should not be given to patients with myasthenia gravis except to reduce adverse muscarinic effects of an anticholinesterase.

Adverse Effects:

In some patients such as in those with arteriosclerosis or a history of drug idiosyncrasy, Benzhexol may produce severe mental disturbances, excitement, nausea and vomiting; such patients should be allowed to develop a tolerance by starting with a small initial dose and gradually increasing it until an effective level is reached.


The effects of Benzhexol and other antimuscarinics may be enhanced by the concomitant administration of other drugs with antimuscarinic properties, such as amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption  of other drugs. Antimuscarinics and parasympathomimetics may counteract each others effects.


Store in a dry place below 25ºC.  Protect from light.  Keep all medicines out of the  reach of children.

Prescription Only Medicine (POM)
Ref. No.: INS092/01.09

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